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KMID : 0811820120160010038
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Journal of Korean Society of Pediatric Nephrology
2012 Volume.16 No. 1 p.38 ~ p.45
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cal Significance of Extended-Spectrum β-Lactamase Producing Escherichia coli in Pediatric Patients with Febrile Urinary Tract Infection
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Park Cheol
Kim Min-Sang
Kim Mi-Kyung
Yim Hyung-Eun
Yoo Kee-Hwan
Hong Young-Sook
Lee Joo-Won
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Abstract
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Purpose: The incidence of community-acquired urinary tract infection (UTI) due to extended-spectrum -lactamase producing (ESBL(+) ) has increased worldwide. ESBL causes resistance to various types of the newer -lactam antibiotics, including the expanded spectrum cephalosporins and monobactams. We aimed to investigate the severity of UTI and associated genitourinary malformations in children with febrile UTI caused by ESBL(+) .
Methods: We retrospectively reviewed the medical records of 290 patients diagnosed as febrile UTI caused by between January 2008 and October 2010 at Korea University Medical center. We classified the patients into two groups with ESBL(+) and ESBL(-) group according to the sensitivity of urine culture. Fever duration, admission period, white blood cell (WBC) counts and C-reactive protein (CRP) in peripheral blood, the presence of hydronephrosis, cortical defects, vesicoureteral reflux (VUR) and renal scar were compared between the two groups.
Results: Patients with ESBL(+) were 32, and those with ESBL(-) were 258. If we excluded those tested with a sterile urine bag, patients with ESBL(+) were 22, and those with ESBL(-) were 212. Whether the results of sterile urine bag tests were included or not, there was no significant difference in all parameters between the two groups statistically.
Conclusion: Our data shows that ESBL(+) may not be related to the severity of UTI and associated genitourinary malformations.
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KEYWORD
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Extended-spectrum β-lactamase, Escherichia coli, Urinary tract infection
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